University of Oulu

STAR-T REK - Set up and comparison of multiple stem cell approaches for kidney repair (223007)

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Description:
"With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potential of this therapeutic approach. Three possible sources of stem cells can be envisioned for the development of this type of treatment: (i) bone-marrow-derived stem cells, (ii) renal adult stem cells, and (iii) fetal renal stem cells. The focus of this project is to assess the regenerative potential of stem cells derived from different sources and investigate the possible obstacles to their utilization, as well as their potential side effects in preclinical models of acute and chronic renal failure. Indeed, the clinical usefulness of the treatment, as well as the need to understand currently discrepant results, require comparative experimental studies that have never been performed before either in SC therapy of kidney injury, or in that of other organs. Hopefully, this comparison will allow to set up standardized protocols of SC isolation and administration for phase I/II trials in patients affected by acute and chronic renal failure."
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Grant Number: 223007
Cordis Record Number: 88607
Project Start Date: 2008-11-01
Project End Date: 2011-10-31
Project Funder: EC/FP7/SP1/HEALTH
EC Special Clause: false
Datapilot: false
Open Access Mandate: false
Coordinator: UNIVERSITA DEGLI STUDI DI FIRENZE
Coordinator contact: Maggi, Enrico
EU Max Contribution: 2999500
Total Cost: 4052900
Participant: UNIVERSITAETSKLINIKUM AACHEN
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
WEIZMANN INSTITUTE OF SCIENCE
THE UNIVERSITY OF EDINBURGH
ACADEMISCH ZIEKENHUIS LEIDEN
MILTENYI BIOTEC GMBH
ALTA Ricerca e Sviluppo in Biotecnologie S.r.l.u.
OULUN YLIOPISTO
ARETA INTERNATIONAL SRL
More information: Detailed project information (CORDIS)
Detailed project information (Openaire)
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All materials created by the OpenAIRE consortium are licensed under a Creative Commons Attribution 4.0 International License
  http://cordis.europa.eu/
https://creativecommons.org/licenses/by/4.0/