INFRAFRONTIER-I3 - Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation (312325) |
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Description: |
The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:
• Develop a series of mutant alleles for every gene in the mouse genome
• Determine the phenotypic consequences of each mutation
• Identify mouse models for the complete disease spectrum in humans
To further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. To this effect, the Infrafrontier-I3 project brings together the leading European centers for systemic phenotyping of mouse mutants and the European Mouse Mutant Archive network. The Infafrontier-I3 partners aim to meet the future challenges presented by phenotyping, archiving and disseminating mouse models in the ERA as follows:
• Contribute to resource development by archiving of 1215 new mouse mutant lines
• Provide free of charge Transnational Access to mouse production and 1st line phenotyping capacities
• Offer a specialized axenic service to produce, maintain and to distribute germ-free mice
• Provide user friendly accession of Infrafrontier services, extensive manual data curation and cross referencing with other mouse database
• Improve user services by developing novel phenotyping and cryopreservation SOPs and by refining innovative research instrumentation
• Engage with the user community using a wide range of PR activities, a dedicated user meeting and an industry liaison workshop
• Offer state of the art cryopreservation and phenotyping training courses
• Benchmark Infrafrontier services with other major repositories
The comprehensive physical and data resources that will be generated by Infrafrontier-I3 will contribute to link basic biomedical research to medical applications and thereby drive innovation and support the Europe 2020 Strategy.
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Subjects: | |
Grant Number: | 312325 |
Cordis Record Number: | 106249 |
Project Start Date: | 2013-01-01 |
Project End Date: | 2016-12-31 |
Project Funder: | EC/FP7/SP4/INFRA |
EC Special Clause: | false |
Datapilot: | false |
Open Access Mandate: | false |
Coordinator: | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH |
Coordinator contact: | Ertel, Jürgen |
Coordinator EU Contribution: | 1879671.36 |
EU Max Contribution: | 9900000 |
Total Cost: | 12431663.54 |
Participant: |
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING Toronto Centre for Phenogenomics Inc. EUROPEAN MOLECULAR BIOLOGY LABORATORY FUNDACAO CALOUSTE GULBENKIAN INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS TSE SYSTEMS GMBH KOBENHAVNS UNIVERSITET MEDICAL RESEARCH COUNCIL HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE CONSIGLIO NAZIONALE DELLE RICERCHE INFRAFRONTIER GMBH TEL AVIV UNIVERSITY OULUN YLIOPISTO KAROLINSKA INSTITUTET VETERINAERMEDIZINISCHE UNIVERSITAET WIEN UNIVERSITAT AUTONOMA DE BARCELONA USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE GENOME RESEARCH LIMITED KATHOLIEKE UNIVERSITEIT LEUVEN |
More information: |
Detailed project information (CORDIS) Detailed project information (Openaire) |
Copyright information: |
© European Union, 1994-2017 CORDIS, http://cordis.europa.eu/ All materials created by the OpenAIRE consortium are licensed under a Creative Commons Attribution 4.0 International License |
http://cordis.europa.eu/ https://creativecommons.org/licenses/by/4.0/ |