Submicron scale tissue multifractal anisotropy in polarized laser light scattering
Das, Nandan Kumar; Dey, Rajib; Chakraborty, Semanti; Panigrahi, Prasanta K.; Meglinski, Igor; Ghosh, Nirmalya (2018-02-01)
Das, N. K., Dey, R., Chakraborty, S., Panigrahi, P. K., Meglinski, I., & Ghosh, N. (2018). Submicron scale tissue multifractal anisotropy in polarized laser light scattering. Laser Physics Letters, 15(3), 35601. https://doi.org/10.1088/1612-202x/aa86f2
© 2018 Astro Ltd. This is an author-created, un-copyedited version of an article published in Laser Physics Letters. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1612-202X/aa86f2.
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https://urn.fi/URN:NBN:fi-fe2019060318266
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Abstract
The spatial fluctuations of the refractive index within biological tissues exhibit multifractal anisotropy, leaving its signature as a spectral linear diattenuation of scattered polarized light. The multifractal anisotropy has been quantitatively assessed by the processing of relevant Mueller matrix elements in the Fourier domain, utilizing the Born approximation and subsequent multifractal analysis. The differential scaling exponent and width of the singularity spectrum appear to be highly sensitive to the structural multifractal anisotropy at the micron/sub-micron length scales. An immediate practical use of these multifractal anisotropy parameters was explored for non-invasive screening of cervical precancerous alterations ex vivo, with the indication of a strong potential for clinical diagnostic purposes.
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