Early probiotic supplementation and the risk of celiac disease in children at genetic risk
Uusitalo, Ulla; Aronsson, Carin Andren; Liu, Xiang; Kurppa, Kalle; Yang, Jimin; Liu, Edwin; Skidmore, Jennifer; Winkler, Christiane; Rewers, Marian J.; Hagopian, William A.; She, Jin-Xiong; Toppari, Jorma; Ziegler, Anette-G; Akolkar, Beena; Norris, Jill M.; Virtanen, Suvi M.; Krischer, Jeffrey P.; Agardh, Daniel; Rewers, Marian; Bautista, Kimberly; Baxter, Judith; Felipe-Morales, Daniel; Driscoll, Kimberly; Frohnert, Brigitte, I; Gallant, Marisa; Gesualdo, Patricia; Hoffman, Michelle; Karban, Rachel; Norris, Jill; Steck, Andrea; Waugh, Kathleen; Simell, Olli G.; Adamsson, Annika; Ahonen, Suvi; Akerlund, Mari; Hekkala, Anne; Holappa, Henna; Hyoty, Heikki; Ikonen, Anni; Ilonen, Jorma; Jaminki, Sinikka; Jokipuu, Sanna; Karlsson, Leena; Kahonen, Miia; Knip, Mikael; Koivikko, Minna-Liisa; Koreasalo, Mirva; Kytola, Jarita; Latva-aho, Tiina; Lindfors, Katri; Lonnrot, Maria; Mantymaki, Elina; Mattila, Markus; Multasuo, Katja; Mykkanenv, Teija; Niininen, Titha; Niinisto, Sari; Nyblom, Mia; Oikarinen, Sami; Ollikainen, Paula; Pohjola, Sirpa; Rajala, Petra; Rautanen, Jenna; Riikonen, Anne; Romo, Minna; Ruohonen, Suvi; Simell, Satu; Sjoberg, Maija; Stenius, Aino; Tossavainen, Paivi; Vaha-Makila, Mari; Vainionpaa, Sini; Varjonen, Eeva; Veijola, Riitta; Viinikangas, Irene; Schatz, Desmond; Hopkins, Diane; Steed, Leigh; Bryant, Jennifer; Silvis, Katherine; Haller, Michael; Gardiner, Melissa; Mclndoe, Richard; Sharma, Ashok; Anderson, Stephen W.; Jacobsen, Laura; Marks, John; Towe, P. D.; Ziegler, Anette G.; Bonifacio, Ezio; D'Angelo, Miryam; Gavrisan, Anita; Gezginci, Cigdem; Heublein, Anja; Hoffmann, Verena; Hummel, Sandra; Keimer, Andrea; Knopff, Annette; Koch, Charlotte; Koletzko, Sibylle; Ramminger, Claudia; Roth, Roswith; Scholz, Marlon; Stock, Joanna; Warncke, Katharina; Wendel, Lorena; Lernmark, Ake; Ask, Maria; Bremer, Jenny; Cilio, Corrado; Ericson-Hallstrom, Emelie; Fors, Annika; Fransson, Lina; Gard, Thomas; Bennet, Rasmus; Hansen, Monika; Hyberg, Susanne; Jisser, Hanna; Johansen, Fredrik; Jonsdottir, Berglind; Jovic, Silvija; Larsson, Helena Elding; Lindstrom, Marielle; Lundgren, Markus; Manson-Martinez, Maria; Markan, Maria; Melin, Jessica; Mestan, Zeliha; Nilsson, Caroline; Ottosson, Karin; Rahmati, Kobra; Ramelius, Anita; Salami, Falastin; Sjoberg, Anette; Sjoberg, Birgitta; Torn, Carina; Wallin, Anne; Wimar, Asa; Aberg, Sofie; Killian, Michael; Crouch, Claire Cowen; Akramoff, Ashley; Chavoshi, Masumeh; Dunson, Kayleen; Hervey, Rachel; Lyons, Rachel; Meyer, Arlene; Mulenga, Denise; Radtke, Jared; Romancik, Matei; Schmitt, Davey; Schwabe, Julie; Zink, Sarah; Becker, Dorothy; Franciscus, Margaret; Smith, Maryellen Dalmagro-Elias; Daftary, Ashi; Klein, Mary Beth; Yates, Chrystal; Austin-Gonzalez, Sarah; Avendano, Maryouri; Baethke, Sandra; Brown, Rasheedah; Burkhardt, Brant; Butterworth, Martha; Clasen, Joanna; Cuthbertson, David; Eberhard, Christopher; Fiske, Steven; Garmeson, Jennifer; Gowda, Veena; Heyman, Kathleen; Hsiao, Belinda; Karges, Christina; Laras, Francisco Perez; Lee, Hye-Seung; Li, Qian; Liu, Shu; Lynch, Kristian; Maguire, Colleen; Malloy, Jamie; McCarthy, Cristina; Merrell, Aubrie; Meulemans, Steven; Parikh, Hemang; Quigley, Ryan; Remedios, Cassandra; Shaffer, Chris; Smith, Laura; Smith, Susan; Sulman, Noah; Tamura, Roy; Tewey, Dena; Toth, Michael; Vehik, Kendra; Vijayakandipan, Ponni; Wood, Keith; Abbondondolo, Michael; Ballard, Lori; Hadley, David; McLeod, Wendy; Yu, Liping; Miao, Dongmei; Bingley, Polly; Williams, Alistair; Chandler, Kyla; Ball, Olivia; Kelland, Ilana; Grace, Sian; Ben Gillard; Hagopian, William; Erlich, Henry; Mack, Steven J.; Fear, Anna Lisa; Ke, Sandra; Mulholland, Niveen; Bourcier, Kasia; Briese, Thomas; Johnson, Suzanne Bennett; Triplett, Eric (2019-08-02)
Uusitalo, U.; Andren Aronsson, C.; Liu, X.; Kurppa, K.; Yang, J.; Liu, E.; Skidmore, J.; Winkler, C.; Rewers, M.J.; Hagopian, W.A.; She, J.-X.; Toppari, J.; Ziegler, A.-G.; Akolkar, B.; Norris, J.M.; Virtanen, S.M.; Krischer, J.P.; Agardh, D.; on behalf of the TEDDY Study Group. Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk. Nutrients 2019, 11, 1790. https://doi.org/10.3390/nu11081790
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2020042822767
Tiivistelmä
Abstract
Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.
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