Ageing and cognition in men with fragile X syndrome
Sauna‐aho, Oili; Bjelogrlic‐Laakso, Nina; Rautava, Päivi; Arvio, Maria (2020-08-07)
Sauna‐aho, O, Bjelogrlic‐Laakso, N, Rautava, P, Arvio, M. Ageing and cognition in men with fragile X syndrome. J Appl Res Intellect Disabil. 2020; 33: 1113– 1118. https://doi.org/10.1111/jar.12733
© 2020 The Authors. Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
https://creativecommons.org/licenses/by-nc/4.0/
https://urn.fi/URN:NBN:fi-fe2020111189931
Tiivistelmä
Abstract
Background: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing‐related cognitive changes in men with FXS.
Method: A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years.
Results: At follow‐up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p < 0.001).
Conclusion: Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause.
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