Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors
Remes, Tiina M.; Hovén, Emma; Ritari, Niina; Pohjasniemi, Heli; Puosi, Riina; Arikoski, Pekka M.; Arola, Mikko O.; Lähteenmäki, Päivi M.; Lönnqvist, Tuula R. I.; Ojaniemi, Marja K.; Riikonen, V. Pekka; Sirkiä, Kirsti H.; Winqvist, Satu; Rantala, Heikki M. J.; Harila, Marika; Harila-Saari, Arja H. (2021-01-22)
Tiina M Remes, Emma Hovén, Niina Ritari, Heli Pohjasniemi, Riina Puosi, Pekka M Arikoski, Mikko O Arola, Päivi M Lähteenmäki, Tuula R I Lönnqvist, Marja K Ojaniemi, V Pekka Riikonen, Kirsti H Sirkiä, Satu Winqvist, Heikki M J Rantala, Marika Harila, Arja H Harila-Saari, Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors, Neuro-Oncology Practice, Volume 8, Issue 3, June 2021, Pages 266–277, https://doi.org/10.1093/nop/npab004
© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2021082444097
Tiivistelmä
Abstract
Background: Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status.
Methods: Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5–33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered.
Results: Survivors’ (median age: 27 years [range: 16–43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49–121) and 87 (range: 43–119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, −3.5 SD [range: −25.0 to 1.3 SD]), and processing speed and attention (median z score, −2.5 SD [range: −24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently.
Conclusions: Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.
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