Physiological effects of the electrogenic current generated by the Na⁺/K⁺ pump in mammalian articular chondrocytes
Maleckar, Mary M.; Martín-Vasallo, Pablo; Giles, Wayne R.; Mobasheri, Ali (2020-09-16)
Maleckar, M. M., Martín-Vasallo, P., Giles, W. R., & Mobasheri, A. (2020). Physiological Effects of the Electrogenic Current Generated by the Na+/K+Pump in Mammalian Articular Chondrocytes. Bioelectricity, 2(3), 258–268. https://doi.org/10.1089/bioe.2020.0036
© Mary M. Maleckar et al. 2020; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.
https://creativecommons.org/licenses/by-nc/4.0/
https://urn.fi/URN:NBN:fi-fe202201031023
Tiivistelmä
Abstract
Background: Although the chondrocyte is a nonexcitable cell, there is strong interest in gaining detailed knowledge of its ion pumps, channels, exchangers, and transporters. In combination, these transport mechanisms set the resting potential, regulate cell volume, and strongly modulate responses of the chondrocyte to endocrine agents and physicochemical alterations in the surrounding extracellular microenvironment.
Materials and methods: Mathematical modeling was used to assess the functional roles of energy-requiring active transport, the Na⁺/K⁺ pump, in chondrocytes.
Results: Our findings illustrate plausible physiological roles for the Na⁺/K⁺ pump in regulating the resting membrane potential and suggest ways in which specific molecular components of pump can respond to the unique electrochemical environment of the chondrocyte.
Conclusion: This analysis provides a basis for linking chondrocyte electrophysiology to metabolism and yields insights into novel ways of manipulating or regulating responsiveness to external stimuli both under baseline conditions and in chronic diseases such as osteoarthritis.
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