Blood graft and outcome after autologous stem cell transplantation in patients with primary central nervous system lymphoma
Partanen, Anu; Kuittinen, Outi; Turunen, Antti; Valtola, Jaakko; Pyörälä, Marja; Kuitunen, Hanne; Vasala, Kaija; Kuittinen, Taru; Mantymaa, Pentti; Pelkonen, Jukka; Jantunen, Esa; Varmavuo, Ville (2021-12-31)
Partanen, A., Kuittinen, O., Turunen, A., Valtola, J., Pyorala, M., Kuitunen, H., Vasala, K., Kuittinen, T., Mantymaa, P., Pelkonen, J., Jantunen, E., & Varmavuo, V. (2021). Blood Graft and Outcome After Autologous Stem Cell Transplantation in Patients With Primary Central Nervous System Lymphoma. Journal Of Hematology, 10(6), 246-254. https://doi.org/10.14740/jh939
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https://urn.fi/URN:NBN:fi-fe2022032425184
Tiivistelmä
Abstract
Background: Autologous stem cell transplantation (auto-SCT) is a treatment option for patients with primary central nervous system lymphoma (PCNSL).
Methods: In this prospective multicenter study, the effects of blood graft cellular content on hematologic recovery and outcome were analyzed in 17 PCNSL patients receiving auto-SCT upfront.
Results: The infused viable CD34⁺ cell count > 1.7 × 10⁶/kg correlated with more rapid platelet engraftment (10 vs. 31 days, P = 0.027) and with early neutrophil recovery (day + 15) (5.4 vs. 1.6 × 10⁹/L, P = 0.047). A higher number of total collected CD34⁺ cells > 3.3 × 106/kg infused predicted worse 5-year progression-free survival (PFS) (33% vs. 100%, P = 0.028). In addition, CD3⁺CD8⁺ T cells > 78 × 10⁶/kg in the infused graft impacted negatively on the 5-year PFS (0% vs. 88%, P = 0.016).
Conclusions: The cellular composition of infused graft seems to impact on the hematologic recovery and PFS post-transplant. Further studies are needed to verify the optimal autograft cellular content in PCNSL.
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