Vimentin suppresses inflammation and tumorigenesis in the mouse intestine
Wang, Linglu; Mohanasundaram, Ponnuswamy; Lindström, Michelle; Asghar, Muhammad Nadeem; Sultana, Giulia; Misiorek, Julia O.; Jiu, Yaming; Chen, Hongbo; Chen, Zhi; Toivola, Diana M.; Cheng, Fang; Eriksson, John E. (2022-03-25)
Wang, L., Mohanasundaram, P., Lindström, M., Asghar, M. N., Sultana, G., Misiorek, J. O., Jiu, Y., Chen, H., Chen, Z., Toivola, D. M., Cheng, F., & Eriksson, J. E. (2022). Vimentin suppresses inflammation and tumorigenesis in the mouse intestine. Frontiers in Cell and Developmental Biology, 10. https://www.frontiersin.org/articles/10.3389/fcell.2022.862237
© 2022 Wang, Mohanasundaram, Lindström, Asghar, Sultana, Misiorek, Jiu, Chen, Chen, Toivola, Cheng and Eriksson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2022060242337
Tiivistelmä
Abstract
Vimentin has been implicated in wound healing, inflammation, and cancer, but its functional contribution to intestinal diseases is poorly understood. To study how vimentin is involved during tissue injury and repair of simple epithelium, we induced colonic epithelial cell damage in the vimentin null (Vim−/−) mouse model. Vim−/− mice challenged with dextran sodium sulfate (DSS) had worse colitis manifestations than wild-type (WT) mice. Vim−/− colons also produced more reactive oxygen and nitrogen species, possibly contributing to the pathogenesis of gut inflammation and tumorigenesis than in WT mice. We subsequently describe that CD11b+ macrophages served as the mainly cellular source of reactive oxygen species (ROS) production via vimentin-ROS-pSTAT3–interleukin-6 inflammatory pathways. Further, we demonstrated that Vim−/− mice did not develop colitis-associated cancer model upon DSS treatment spontaneously but increased tumor numbers and size in the distal colon in the azoxymethane/DSS model comparing with WT mice. Thus, vimentin has a crucial role in protection from colitis induction and tumorigenesis of the colon.
Kokoelmat
- Avoin saatavuus [31995]