Sleep in psychotic disorders : results from nationwide SUPER Finland study
Cederlöf, Erik; Holm, Minna; Lähteenvuo, Markku; Haaki, Willehard; Hietala, Jarmo; Häkkinen, Katja; Isometsä, Erkki; Jukuri, Tuomas; Kajanne, Risto; Kampman, Olli; Kieseppä, Tuula; Lahdensuo, Kaisla; Lönnqvist, Jouko; Männynsalo, Teemu; Niemi-Pynttäri, Jussi; Suokas, Kimmo; Suvisaari, Jaana; Tiihonen, Jari; Turunen, Hannu; Wegelius, Asko; Veijola, Juha; Palotie, Aarno; Paunio, Tiina (2022-02-03)
Erik Cederlöf, Minna Holm, Markku Lähteenvuo, Willehard Haaki, Jarmo Hietala, Katja Häkkinen, Erkki Isometsä, Tuomas Jukuri, Risto Kajanne, Olli Kampman, Tuula Kieseppä, Kaisla Lahdensuo, Jouko Lönnqvist, Teemu Männynsalo, Jussi Niemi-Pynttäri, Kimmo Suokas, Jaana Suvisaari, Jari Tiihonen, Hannu Turunen, Asko Wegelius, Juha Veijola, Aarno Palotie, Tiina Paunio, Sleep in Psychotic Disorders: Results From Nationwide SUPER Finland Study, Schizophrenia Bulletin Open, Volume 3, Issue 1, January 2022, sgac011, https://doi.org/10.1093/schizbullopen/sgac011
© The Author(s) 2022. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
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https://urn.fi/URN:NBN:fi-fe2022092259855
Tiivistelmä
Abstract
Objective: Characterizing sleep in patients with schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic depression.
Methods: This cross-sectional questionnaire study is based on the SUPER study sample, which is part of the Stanley Global Neuropsychiatric Genomics Initiative. The study is a multicentre, nationwide Finnish study consisting of patients (N = 8 623) both in primary and specialized health care. The main measurements were sleep duration, difficulties initiating sleep, early morning awakenings, and fatigue. These results were compared with a nationally representative sample of the Finnish population from the Health 2000 survey (N = 7 167) with frequency and logistic regression analyses.
Results: Patients had more sleep problems compared with the general population, especially young and middle-aged patients (Difficulties initiating sleep in young patients odds ratio = 12.3, 95% CI 9.8–15.4). Long sleep duration was the most deviating property of the sleep characteristics, being particularly common among young patients with schizophrenia (odds ratio = 27.9, 95% CI 22.1–35.2, 47.4% vs 3.3% prevalence). All sleep problems were associated with worse subjective health. We also conducted a latent class analysis, resulting in a cluster relatively free of sleep problems (58% of patients), an insomnia symptom cluster (26%), and a hypersomnia symptom cluster (15%).
Conclusions: In our sample, patients with psychotic disorders have more sleep problems—especially long sleep duration but also insomnia symptoms—compared with the general population. The patients can in a latent class analysis of their sleep symptoms be divided into groups with differing sleep profiles.
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